Disease candidate gene identification and prioritization using protein interaction networks
نویسندگان
چکیده
منابع مشابه
Identification and prioritization genes related to Hypercholesterolemia QTLs using gene ontology and protein interaction networks
Gene identification represents the first step to a better understanding of the physiological role of the underlying protein and disease pathways, which in turn serves as a starting point for developing therapeutic interventions. Familial hypercholesterolemia is a hereditary metabolic disorder characterized by high low-density lipoprotein cholesterol levels. Hypercholesterolemia is a quantitativ...
متن کاملCorrection: Disease candidate gene identification and prioritization using protein interaction networks
Text After the publication of this work [1], we became aware of the fact that we inadvertently failed to include the work of Chen et al. [2] when listing previous studies that use PPIs to prioritize disease candidate genes. In a pioneering study [2], Chen et al. used a initial gene list for Alzheimer's from the OMIM database, expanded it based on protein interactions, and proposed a scoring fun...
متن کاملidentification and prioritization genes related to hypercholesterolemia qtls using gene ontology and protein interaction networks
gene identification represents the first step to a better understanding of the physiological role of the underlying protein and disease pathways, which in turn serves as a starting point for developing therapeutic interventions. familial hypercholesterolemia is a hereditary metabolic disorder characterized by high low-density lipoprotein cholesterol levels. hypercholesterolemia is a quantitativ...
متن کاملExploiting Protein-Protein Interaction Networks for Genome-Wide Disease-Gene Prioritization
Complex genetic disorders often involve products of multiple genes acting cooperatively. Hence, the pathophenotype is the outcome of the perturbations in the underlying pathways, where gene products cooperate through various mechanisms such as protein-protein interactions. Pinpointing the decisive elements of such disease pathways is still challenging. Over the last years, computational approac...
متن کاملDisease Gene Prioritization Based on Topological Similarity in Protein-Protein Interaction Networks
In recent years, many algorithms have been developed to narrow down the set of candidate disease genes implicated by genome wide association studies (GWAS), using knowledge on protein-protein interactions (PPIs). All of these algorithms are based on a common principle; functional association between proteins is correlated with their connectivity/proximity in the PPI network. However, recent res...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2009
ISSN: 1471-2105
DOI: 10.1186/1471-2105-10-73